AI-Powered PRGX Clinical Trial Contract Management
Recover millions from closed trials. Prevent costly errors on open trials. Strengthen terms going forward.
PRGX Contract Management helps pharmaceutical, biotech, and life sciences companies take control of clinical trial management costs across CRO and site contracts worldwide.
PRGX Contract Management helps pharmaceutical, biotech, and life sciences companies take control of clinical trial management costs across CRO and site contracts worldwide.
The Hidden Cost of Complexity and Speed
Clinical trials are among the most complex supplier management challenges in the pharmaceutical supply chain—multi-year programs that can span dozens of countries, hundreds of sites, and thousands of invoices. And the pressure to move fast only increases risk.
Behind every trial is a web of supplier contracts. Pricing mechanics vary across agreements: pass-through costs, cost plus, time and material, consumables, and fixed-price milestones. Add down payments, multi-year amendments, and foreign exchange across regions—and complexity compounds.
The result? Financial losses hide in plain sight. Most companies don’t discover them until after study closeouts and key players have moved on.
More Trials, Less Margin
Clinical trial investment is surging—driven by the GLP-1/weight loss drug race, AI-accelerated discovery, oncology breakthroughs, and gene therapies. More trials, more sites, more CROs, more complexity—and more exposure to contract overruns or errors.
But margin pressure is intensifying. Patent cliffs, biosimilar competition, global pricing pressures, and PBM negotiations demand tighter cost control.
Strong revenue doesn’t eliminate the need for cost recovery. And the backlog is real—years of unaudited spend sitting in closed trials while money drains in real-time on open trials.
Why PRGX
Catch What Others Miss
Most companies accept payment errors as a cost of doing business—lacking visibility, relying on CROs to self-report, and carrying the same gaps trial to trial. PRGX changes that.
AI That Finds More
Contract Insights™ AI ingests thousands of contracts via API—organizing and making them auditable in days, not months. 105+ clause types analyzed.
Stronger Contract Performance
Contract Compliance reveals gaps. Contract Optimization closes them. Contract Monitoring ensures terms are honored. Three solutions designed to work together.
PRGX Contract Management: By the Numbers
Trusted by leading global pharmaceutical and biotech organizations to manage billions in clinical trial spend.
Sample Clinical Trial Results
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0
Million
Auditable Spend Reviewed
$
0
Million
Corrective Actions Identified
$
0
Million
Cash Recoveries Realized
Results from a Fortune 500 pharmaceutical engagement. Outcomes vary by trial complexity and data availability.
PRGX Contract Management:
Three Solutions, One Continuous Cycle
Just as clinical trials progress through defined phases—each building on the learnings of the last—PRGX Contract Management follows a similar logic.
Start with one solution or combine all three for maximum savings—PRGX Contract Management meets you where you are.
Watch the Video to learn more.
Powered by Contract Insights™ AI
Our platform enables rapid AI contract reviews at scale across your clinical research portfolio:
- Ingest 10,000+ documents via API (Ariba, Coupa) or direct upload
- Organize contracts, amendments, task orders, and change documents into auditable format
- Compare payment terms, visit definitions, and expense policies across your portfolio
- Flag duplicates, anomalies, unreconciled down payments, and FX discrepancies
- Prioritize contracts by recovery potential
Spend analytics plus deep Contract Management expertise—that’s how we find what others miss.
Amit Dingare, Chief AI Officer, PRGX describes the Seven Steps to Saving Millions with Contract Insights.
Ready to Take Control?
Contract Compliance engagements are designed to be self-funding and cash-positive—delivering recoveries that exceed program costs. Contract Optimization and Contract Monitoring deliver cost avoidance that prevents cash going out your door.
AI-Powered PRGX Clinical Trial Contract Management
What can PRGX do before a clinical trial begins?
We partner with your clinical operations and life sciences procurement teams to optimize agreements before any payments are made:
- Contract review and optimization of draft CTAs, site agreements, and investigator contracts
- Fair market value assessment to ensure per-visit payments align with industry benchmarks
- Payment term standardization to clearly define visit types, screen failure compensation, and early termination scenarios
- Expense policy alignment to establish clear travel reimbursement guidelines and documentation requirements
- Foreign exchange provisions to protect against exchange rate volatility
- Volume discount structuring to capture savings across multi-site or multi-study arrangements
Contract Optimization before signing prevents the gaps that create losses later.
What can PRGX do for open clinical trials?
We provide historical payment reviews with Contract Compliance for open clinical trials—even for ones already underway. This includes year-end reconciliation, pass-through cost validation, invoice validation, vendor payment verification, discount application, FTE and rate card checks, time charges against timesheets, travel expense audits, foreign exchange checks, duplicate charge detection, and rebate tracking. Contract Monitoring matches invoices and payments to contract terms—even across complex categories.
As trials scale and amendments arise, we recommend contract improvements in real time through ongoing spend management and procurement compliance. We can address discrepancies with sites and CROs as they occur—minimizing disputes at closeout.
What can PRGX do for closed clinical trials?
Even after supplier reconciliation, errors can persist—reviews aren’t always comprehensive, and supporting documentation may be incomplete. In some cases, studies remain unreconciled for years.
We conduct comprehensive Contract Compliance audits—applying all the checks we do for open trials. This includes comparing all payments against contract terms, reconciling down payments and true-ups, validating rebates and discounts, and performing root cause analysis for future prevention.
Time matters: CROs retain records for 5-6 years post-trial, but system changes and archiving means older records can be harder to access. The longer you wait, the more difficult cost recovery becomes.
What types of errors do you find with clinical trials?
Common findings include:
- Inaccurate visit payments and ghost visits for patients no longer in trial
- Overcharges after screen failures, early terminations, or early dismissals
- Duplicate billing and investigators paid under multiple sites
- Travel expenses not allowed by contract, exceeding policy, or lacking documentation
- Down payments not properly reconciled or drawn down
- Rebates applied at budget level but not flowing through to actuals
- Foreign exchange errors across multi-country studies
What are the benefits of PRGX Clinical Trial Contract Management?
Our program delivers measurable value across your clinical operations:
- Cash Recovery & Cost Recovery — Recoup overpayments from closed and open trials
- Cost Avoidance — Prevent future losses through optimized contract terms
- Vendor Compliance & Procurement Compliance — Ensure site and vendor adherence to negotiated terms
- Enhanced Visibility — Gain real-time insight into clinical trial payments across your portfolio
- Spend Management — Comprehensive oversight of your pharma supply chain spend
- Standardization — Implement consistent contract language and payment structures across studies
- Reduced Dispute Risk — Address issues in real-time during the trial, before closeout
- Continuous Improvement — Apply lessons learned to future trial budgets and agreements
How is PRGX Contract Management different?
We combine AI-powered contract audit and AI contract review capabilities (105+ clause types, 10,000+ documents in days) with 90+ Contract Management specialists who average 10+ years procurement/finance expertise. We operate across five continents, conduct 700+ supplier audits annually, and take a vendor-sensitive approach that preserves critical research relationships.
Is my data secure?
Yes. We maintain ISO 27001 certification and FSQS registration.
