CLINICAL TRIALS CONTRACT MANAGEMENT
Purpose-Built AI Finds The Hidden Costs In Your Clinical Trials
Recover millions. Prevent costly errors. Strengthen supplier terms. Take control of clinical trial spend.
Why Clinical Trial Costs Are Harder to Control Than Ever
Clinical trial complexity is intensifying. More trials driven by GLP-1 development, AI-accelerated discovery, and gene therapies mean more sites, more Contract Research Organizations (CROs), and more exposure to contract overcharges.
Meanwhile, margin pressure mounts from patent cliffs, biosimilar competition, and pricing pressures. Yet most companies lack visibility into trial payments — relying on CROs to self-report while errors accumulate across pass-through costs, milestones, and FX fluctuations.
The result? Financial losses hide in plain sight, often undiscovered until after study closeout when recovery becomes exponentially harder.
Key Challenge Points:
- Multi-year programs spanning dozens of countries and hundreds of sites
- Complex pricing: pass-through costs, cost-plus, T&M, fixed milestones
- Down payments, amendments, and FX compounding risk
- Years of unaudited spend and real-time cash drain
PRGX Contract Management:
Three Solutions, One Continuous Cycle
Just as clinical trials progress through defined phases—each building on the learnings of the last—PRGX Contract Management follows a similar logic.
Start with one solution or combine all three for maximum savings—PRGX Contract Management meets you where you are.
Watch the Video to learn more.
Built for Pharma Complexity,
Powered by Contract Insights™ AI
Our platform enables rapid AI contract reviews at scale across your clinical research portfolio:
- Ingest 10,000+ documents via API (Ariba, Coupa) or direct upload
- Organize contracts, amendments, task orders, and change documents into auditable format
- Compare payment terms, visit definitions, and expense policies across your portfolio
- Flag duplicates, anomalies, unreconciled down payments, and FX discrepancies
- Prioritize contracts by recovery potential
Spend analytics plus deep Contract Management expertise—that’s how we find what others miss.
Amit Dingare, Chief AI Officer, PRGX describes the Seven Steps to Saving Millions with Contract Insights.
Access the eBook, From Complexity to Clarity: Unlock Contract Savings in Clinical Trials, to learn how to recover cash now, prevent future leakage, and build stronger terms across your trial portfolio.
Case Study: Clinical Trial Contract Management
$ 0 Million
Auditable Spend Reviewed
$ 0 Million
Corrective Actions Identified
$ 0 Million
Cash Recoveries Realized
Results from a Fortune 500 pharmaceutical engagement. Outcomes vary by trial complexity and data availability.
“PRGX operates as a true extension of our team. We trust their expertise completely, which allows us to stay hands-off while knowing the work is being done to the highest standard. That level of autonomy and confidence is incredibly valuable to us.”
- VP of Finance, Global Pharmaceutical Company
By the Numbers
With PRGX Contract Management, our global team of pharmaceutical and biotech audit experts leverages proprietary AI technology to deliver clinical trial compliance and cash recoveries.
Trusted by leading global pharmaceutical and biotech organizations to manage billions in clinical trial spend.
Our Global Partners Include
Ready to Take Control?
Contract Compliance engagements are designed to be self-funding and cash-positive—delivering recoveries that exceed program costs. Contract Optimization and Contract Monitoring deliver cost avoidance that prevents cash going out your door.
Why PRGX? Discover. Recover. Prevent.
Healthier Margins
We recover more than $2 billion annually and 10x ROI (on average) for our clients
Stronger Relationships
We help you maintain and nurture valuable supplier relationships while recovering profit.
Stronger Contract Performance
Contract Compliance reveals gaps. Contract Optimization closes them. Contract Monitoring ensures terms are honored. Three solutions designed to work together.
AI-Powered PRGX Clinical Trial Contract Management
What can PRGX do before a clinical trial begins?
We partner with your clinical operations and life sciences procurement teams to optimize agreements before any payments are made:
- Contract review and optimization of draft CTAs, site agreements, and investigator contracts
- Fair market value assessment to ensure per-visit payments align with industry benchmarks
- Payment term standardization to clearly define visit types, screen failure compensation, and early termination scenarios
- Expense policy alignment to establish clear travel reimbursement guidelines and documentation requirements
- Foreign exchange provisions to protect against exchange rate volatility
- Volume discount structuring to capture savings across multi-site or multi-study arrangements
Contract Optimization before signing prevents the gaps that create losses later.
What can PRGX do for open clinical trials?
We provide historical payment reviews with Contract Compliance for open clinical trials—even for ones already underway. This includes year-end reconciliation, pass-through cost validation, invoice validation, vendor payment verification, discount application, FTE and rate card checks, time charges against timesheets, travel expense audits, foreign exchange checks, duplicate charge detection, and rebate tracking. Contract Monitoring matches invoices and payments to contract terms—even across complex categories.
As trials scale and amendments arise, we recommend contract improvements in real time through ongoing spend management and procurement compliance. We can address discrepancies with sites and CROs as they occur—minimizing disputes at closeout.
What can PRGX do for closed clinical trials?
Even after supplier reconciliation, errors can persist—reviews aren’t always comprehensive, and supporting documentation may be incomplete. In some cases, studies remain unreconciled for years.
We conduct comprehensive Contract Compliance audits—applying all the checks we do for open trials. This includes comparing all payments against contract terms, reconciling down payments and true-ups, validating rebates and discounts, and performing root cause analysis for future prevention.
Time matters: CROs retain records for 5-6 years post-trial, but system changes and archiving means older records can be harder to access. The longer you wait, the more difficult cost recovery becomes.
What types of errors do you find with clinical trials?
Common findings include:
- Inaccurate visit payments and ghost visits for patients no longer in trial
- Overcharges after screen failures, early terminations, or early dismissals
- Duplicate billing and investigators paid under multiple sites
- Travel expenses not allowed by contract, exceeding policy, or lacking documentation
- Down payments not properly reconciled or drawn down
- Rebates applied at budget level but not flowing through to actuals
- Foreign exchange errors across multi-country studies
What are the benefits of PRGX Clinical Trial Contract Management?
Our program delivers measurable value across your clinical operations:
- Cash Recovery & Cost Recovery — Recoup overpayments from closed and open trials
- Cost Avoidance — Prevent future losses through optimized contract terms
- Vendor Compliance & Procurement Compliance — Ensure site and vendor adherence to negotiated terms
- Enhanced Visibility — Gain real-time insight into clinical trial payments across your portfolio
- Spend Management — Comprehensive oversight of your pharma supply chain spend
- Standardization — Implement consistent contract language and payment structures across studies
- Reduced Dispute Risk — Address issues in real-time during the trial, before closeout
- Continuous Improvement — Apply lessons learned to future trial budgets and agreements
How is PRGX Contract Management different?
We combine AI-powered contract audit and AI contract review capabilities (105+ clause types, 10,000+ documents in days) with 90+ Contract Management specialists who average 10+ years procurement/finance expertise. We operate across five continents, conduct 700+ supplier audits annually, and take a vendor-sensitive approach that preserves critical research relationships.
Is my data secure?
Yes. We maintain ISO 27001 certification and FSQS registration.
